ISDA: 21LT

Deposition Date 2025-12-17

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

21LT

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of the setmelanotide-bound human melanocortin receptor 4 (MC4R)-Gq complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.11 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:G subunit q (Gi1-Gq chimeric)
Chain IDs:C (auth: A)
Chain Length:361
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:D (auth: B)
Chain Length:371
Number of Molecules:1
Biological Source:Rattus norvegicus, synthetic construct

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:E (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

Polymer Type:polypeptide(L)
Molecule:Setmelanotide
Chain IDs:A (auth: P)
Chain Length:8
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Melanocortin receptor 4,LgBiT
Chain IDs:B (auth: R)
Chain Length:505
Number of Molecules:1
Biological Source:Homo sapiens, synthetic construct

Ligand Molecules

Primary Citation

Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders

Feng, W, Zhou, Q, Wang, M.W.Show

Acta Pharm Sin B ? ? ? (2026)

DOI: 10.1016/j.apsb.2026.06.035

Primary Citation of related structures

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