ISDA: 21LT

Deposition Date 2025-12-17

Release Date 2026-08-12

Last Version Date 2026-08-26

Entry Detail

PDB ID:

21LT

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of the setmelanotide-bound human melanocortin receptor 4 (MC4R)-Gq complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.11 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:G subunit q (Gi1-Gq chimeric)
Chain IDs:C (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:D (auth: B)
Chain Length:0
Number of Molecules:1
Biological Source:Rattus norvegicus, synthetic construct

UniProt ID:P54311 Pfam ID:PF25391

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:E (auth: G)
Chain Length:0
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Polymer Type:polypeptide(L)
Molecule:Setmelanotide
Chain IDs:A (auth: P)
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Melanocortin receptor 4,LgBiT
Gene (Uniprot):MC4R
Chain IDs:B (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens, synthetic construct

UniProt ID:P32245 Pfam ID:PF00001

Ligand Molecules

Primary Citation

Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders.

Feng, W, Zhou, Q, Wang, M.W.Show

Acta Pharm Sin B 16 5016 5033 (2026)

PMID: 42592034 DOI: 10.1016/j.apsb.2026.06.035

Primary Citation of related structures

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