ISDA: 21BX

Deposition Date 2025-12-07

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

21BX

Keywords:

PROTEIN FIBRIL

Title:

Cryo-EM structure of Orb2 amyloid from 30-day-old Drosophila (4Hb)

Biological Source:

Source Organism(s):

Drosophila melanogaster (Taxon ID: 7227)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.64 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translational regulator orb2
Gene (Uniprot):orb2
Chain IDs:A, B, C (auth: P), D (auth: M), E (auth: N), F (auth: H), G (auth: O), H (auth: E), I (auth: F), J (auth: D), K (auth: G), L, M (auth: C), N (auth: I), O (auth: J), P (auth: T), Q (auth: K), R (auth: Q), S (auth: R), T (auth: S)
Chain Length:31
Number of Molecules:20
Biological Source:Drosophila melanogaster

UniProt ID:Q9VSR3

Ligand Molecules

Primary Citation

Age-dependent structural evolution of a functional amyloid contributes to memory impairment in Drosophila.

Ou, S, Guillen-Poza, P.A, Ng, K.K, Xu, L, Cheng, B.Y, Yi, Y, Ho, L.Y, Franco-Fernandez, A, Khaki, P.S.S, Mukhi, M, Cheung, K.C, Sharma, R, Oroz, J, Hirano, Y, Hervas, R.Show

Cell ? ? ? (2026)

PMID: 42962658 DOI: 10.1016/j.cell.2026.10.009

Primary Citation of related structures

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