20ZX image
Deposition Date 2025-12-04
Release Date 2026-06-17
Last Version Date 2026-06-24
Entry Detail
PDB ID:
20ZX
Title:
Cryo-EM structure of Gq-coupled LPAR5 in complex with LPA
Biological Source:
Source Organism(s):
Rattus norvegicus (Taxon ID: 10116)
Bos taurus (Taxon ID: 9913)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.96 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:D (auth: A)
Chain Length:361
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:A (auth: B)
Chain Length:371
Number of Molecules:1
Biological Source:Rattus norvegicus
Protein Blast
Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:E
Chain Length:247
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: G)
Chain Length:70
Number of Molecules:1
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Lysophosphatidic acid recepto
Gene (Uniprot):LPAR5
Chain IDs:C (auth: R)
Chain Length:372
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
Primary Citation
Structural basis for lysophosphatidic acid recognition and atypical G(a)q coupling by LPAR5
Li, X.Show
Proc.Natl.Acad.Sci.USA ? ? ? (2026)
DOI: 10.1073/pnas.2537482123
Primary Citation of related structures
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