ISDA: 13FJ

Deposition Date 2026-05-04

Release Date 2026-06-17

Last Version Date 2026-07-29

Entry Detail

PDB ID:

13FJ

Keywords:

CYTOKINE

Title:

TGFB1 IN COMPLEX WITH NIS793 FAB

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.75 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transforming growth factor be
Gene (Uniprot):TGFB1
Chain IDs:A, B
Chain Length:112
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01137 Pfam ID:PF00019

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:NIS793 Fab heavy chain
Chain IDs:C (auth: H), D (auth: I)
Chain Length:224
Number of Molecules:2
Biological Source:Homo sapiens

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:NIS793 Fab light chain
Chain IDs:E (auth: L), F (auth: M)
Chain Length:214
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

SO4

Primary Citation

Biomarker analysis from patients with metastatic PDAC treated with TGF beta antibody, NIS793, plus abraxane+gemcitabine vs. abraxane+gemcitabine alone in a phase II, open label, randomized study.

Pelletier, M, Yang, J, Joshi, M, Grauel, A, Abecunas, C, Altzerinakou, M.A, Zhou, Z, Zhu, X, Clark, K, Li, L, Bai, L.Y, Milella, M, Mercade, T.M, Tai, W.M.D, Bockorny, B, Grell, P, Sivakumar, S, Wong, M.K, Chee, C.E, Aparicio, T, Prager, G, Bostel, G, Schiessl, B, Maacke, H, Dranoff, G, Shaw, A, Fabre, C, Mataraza, J, Malek, S, Cremasco, V.Show

Clin.Cancer Res. ? ? ? (2026)

PMID: 42347868 DOI: 10.1158/1078-0432.CCR-26-0805

Primary Citation of related structures

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