ISDA: 12YZ

Deposition Date 2026-04-23

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

12YZ

Keywords:

TRANSFERASE

Title:

Crystal structure of human K293st geranylgeranyl diphosphate synthase with 5 geranylgeranyl diphosphate bound and 1 magnesium only subunits

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.82 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.17

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Geranylgeranyl pyrophosphate
Gene (Uniprot):GGPS1
Chain IDs:A, B, C, D, E, F
Chain Length:294
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:O95749 EC:2.5.1.29

Ligand Molecules

GRG

Primary Citation

Mapping Ligand-Induced Conformational Changes during the Enzymatic Cycle of Human Geranylgeranyl Diphosphate Synthase.

Pham, A.C, Struble, L.R, Amunugama, L, Shaw, J.B, Stachowski, T.R, Holstein, S.A, Borgstahl, G.E.O.Show

Biochemistry ? ? ? (2026)

PMID: 42895111 DOI: 10.1021/acs.biochem.6c00411

Primary Citation of related structures

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