ISDA: 12WB

Deposition Date 2026-04-20

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

12WB

Keywords:

VIRAL PROTEIN/INHIBITOR

Title:

The structure of the C117D variant of the COVID-2 main protease in complex with GC-376

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli k-12

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.25 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Mutagens:C117D
Chain IDs:A, B (auth: C)
Chain Length:306
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

Ligand Molecules

K36

Primary Citation

The C117D oxidation mimic reveals the monomeric structure of SARS-CoV-2 main protease.

Andress, S, McLeod, M.J, Holyoak, T.Show

Protein Sci. 35 e70753 e70753 (2026)

PMID: 42572186 DOI: 10.1002/pro.70753

Primary Citation of related structures

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