12VU image
Deposition Date 2026-04-20
Release Date 2026-08-19
Last Version Date 2026-08-19
Entry Detail
PDB ID:
12VU
Keywords:
VIRAL PROTEIN
Title:
The structure of the C145D variant of the COVID-2 main protease
Biological Source:
Source Organism(s):
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.75 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 1 21 1
12VU validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Mutagens:C145D
Chain IDs:A, B
Chain Length:306
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2
Primary Citation
The C117D oxidation mimic reveals the monomeric structure of SARS-CoV-2 main protease.
Protein Sci. 35 e70753 e70753 (2026)
PMID: 42572186 DOI: 10.1002/pro.70753
Primary Citation of related structures
12VR
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