12PL image
Deposition Date 2026-04-14
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
12PL
Keywords:
TRANSFERASE
Title:
Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with LMS
Biological Source:
Source Organism(s):
Trypanosoma cruzi (Taxon ID: 5693)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.82 Å
R-Value Free:
0.27
R-Value Work:
0.24
R-Value Observed:
0.24
Space Group:
P 31 2 1
12PL validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine protein kina
Gene (Uniprot):Tc00.1047053508479.150
Mutagens:T185I, V227F, N314S
Chain IDs:A, B
Chain Length:361
Number of Molecules:2
Biological Source:Trypanosoma cruzi
UniProt ID:Q4E2L0 Pfam ID:PF00069
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP A SER modified residue
Ligand Molecules
LMS
Primary Citation
Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with LMS
To be published ? ? ? (?)
Primary Citation of related structures
12PL
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