ISDA: 12LU

Deposition Date 2026-04-12

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

12LU

Keywords:

FLAVOPROTEIN

Title:

LSD1-CoREST in complex with GSK-LSD1 and peptide PRSALV

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.20 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

I 2 2 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lysine-specific histone demet
Gene (Uniprot):KDM1A
Chain IDs:A
Chain Length:871
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60341 EC:1.14.11.65

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:REST corepressor 1
Gene (Uniprot):RCOR1
Chain IDs:B
Chain Length:144
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UKL0

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:PRSAL
Chain IDs:C (auth: E)
Chain Length:6
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

FAJ

Primary Citation

Covalent Chemical Rescue of a Transcription Factor-Corepressor Complex

Liu, C, Yost, K, Kwok, H.S, Caroli, J, Waterbury, A.L, Gankhuyag, N, Zhang, O, Harry, S.A, Hansen, T.N, Roh, H, Furui, A, Mattevi, A, Liau, B.B.Show

Acs Cent.Sci. ? ? ? (2026)

DOI: 10.1021/acscentsci.6c01320

Primary Citation of related structures

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