ISDA: 12LG

Deposition Date 2026-04-10

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

12LG

Keywords:

OXIDOREDUCTASE

Title:

Mtb GuaB2 dCBS in complex with inhibitor G9

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis (Taxon ID: 1773)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.35 Å

R-Value Free:

0.17

R-Value Work:

0.13

R-Value Observed:

0.13

Space Group:

I 4

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Inosine-5'-monophosphate dehy
Gene (Uniprot):guaB
Chain IDs:A
Chain Length:422
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

UniProt ID:P65168 EC:1.1.1.205

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
CSO	A	CYS	modified residue

Ligand Molecules

A1DCN

IMP

Primary Citation

Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection.

Kofoed, E.M, Crawford, T.D, Bowman, C.M, Sims, J, Dening, T.J, Wang, S, Zhou, Y, Harris, S.F, Xu, M, Wu, P, Yang, Y, Wong, M.K, Corpuz, R, Xu, Y, Ganti, A, Ubhayakar, S, Hu, C, Clark, K.R, Cai, Z, Lai, K.W, Wang, X, Zhang, R, Koehler, M.F.T, Hanan, E.J, Aliagas, I, Ng, J, Silverman, J, Mdluli, K, Kapadia, S, Tan, M.W.Show

Acs Infect Dis. 12 3373 3384 (2026)

PMID: 42917107 DOI: 10.1021/acsinfecdis.6c00350

Primary Citation of related structures

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