12GT image
Deposition Date 2026-04-04
Release Date 2026-11-11
Last Version Date 2026-11-11
Entry Detail
PDB ID:
12GT
Keywords:
Title:
HDAC1-MTA1 in complex with WNA0 (7-(dimethylamino)-1-(5-(thiophen-2-yl)isoxazol-3-yl)heptan-1-one), a nonhydrolyzable analog of WNA1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.56 Å
R-Value Free:
0.24
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 32 2 1
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Metastasis-associated protein
Gene (Uniprot):MTA1
Chain IDs:A
Chain Length:195
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Histone deacetylase 1
Gene (Uniprot):HDAC1
Chain IDs:B
Chain Length:482
Number of Molecules:1
Biological Source:Homo sapiens
Primary Citation
A conformation-sensitive product inhibitor of HDAC1/2 potentiates WNT signaling
Nat.Chem.Biol. ? ? ? (2026)
DOI: 10.1038/s41589-026-02385
Primary Citation of related structures
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