ISDA: 12AX

Deposition Date 2026-03-24

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

12AX

Keywords:

TRANSFERASE

Title:

Human Ornithine Aminotransferase soaked with its inhibitor, (3S,4R)-3-amino-4-ethynylcyclopent-1-ene-1-carboxylic acid

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.58 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 32 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Ornithine aminotransferase, m
Chain IDs:A, B, C
Chain Length:439
Number of Molecules:3
Biological Source:Homo sapiens

Ligand Molecules

A1DBA

GOL

Primary Citation

Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of gamma-Aminobutyric Acids.

Wang, F, Corrigan, M.C, Le, N.H.V, Duan, D, Smith, C.O, Moran, G.R, Kelleher, N.L, Liu, D, Silverman, R.B.Show

J.Am.Chem.Soc. 148 30301 30313 (2026)

PMID: 42429780 DOI: 10.1021/jacs.6c08456

Primary Citation of related structures

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