ISDA: 12AV

Deposition Date 2026-03-24

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

12AV

Keywords:

TRANSFERASE

Title:

Human Ornithine Aminotransferase cocrystallized with its inhibitor,(3S,4S)-3-amino-4-cyanocyclopent-1-ene-1-carboxylic acid

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.51 Å

R-Value Free:

0.18

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

C 1 2 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Ornithine aminotransferase, m
Chain IDs:A (auth: B), B (auth: A), C, D, E, F, G, H, I
Chain Length:439
Number of Molecules:9
Biological Source:Homo sapiens

Ligand Molecules

A1DBF

Primary Citation

Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of gamma-Aminobutyric Acids.

Wang, F, Corrigan, M.C, Le, N.H.V, Duan, D, Smith, C.O, Moran, G.R, Kelleher, N.L, Liu, D, Silverman, R.B.Show

J.Am.Chem.Soc. 148 30301 30313 (2026)

PMID: 42429780 DOI: 10.1021/jacs.6c08456

Primary Citation of related structures

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