12AO image
Deposition Date 2026-03-23
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
12AO
Keywords:
VIRAL PROTEIN
Title:
Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with fusion inhibitor peptide DP142014
Biological Source:
Source Organism(s):
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (Taxon ID: 211044)
Papillomaviridae (Taxon ID: 151340)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.85 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
I 21 3
12AO validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Hemagglutinin
Gene (Uniprot):HA
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Influenza A virus (A/Puerto Rico/8/1934(H1N1))
UniProt ID:P03452 Pfam ID:PF00509
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Hemagglutinin HA2 chain
Gene (Uniprot):HA
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Influenza A virus (A/Puerto Rico/8/1934(H1N1))
UniProt ID:P03452 Pfam ID:PF00509
Polymer Type:polypeptide(L)
Molecule:Synthetic peptide
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Papillomaviridae
Ligand Molecules
NAG
Primary Citation
Antibody hotspot-centric de novo design of peptide inhibitors of influenza A virus membrane fusion
To Be Published ? ? ? (?)
Primary Citation of related structures
12AO
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