11YB image
Deposition Date 2026-03-17
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
11YB
Keywords:
BLOOD CLOTTING
Title:
Structure of AlphaIIbBeta3-R21C11 Fab in the near-bent conformation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Homo sapiens, Mus musculus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
11YB validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Integrin alpha-IIb
Gene (Uniprot):ITGA2B
Chain IDs:A
Chain Length:1039
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P08514 Pfam ID:PF01839, PF08441, PF20805, PF20806, PF00357
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Integrin beta-3
Gene (Uniprot):ITGB3
Chain IDs:B
Chain Length:788
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P05106 Pfam ID:PF17205, PF00362, PF18372, PF23105, PF07974, PF07965, PF08725
Polymer Type:polypeptide(L)
Molecule:R21C11 Fab heavy chain
Chain IDs:C (auth: H)
Chain Length:221
Number of Molecules:1
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:R21C11 Fab light chain
Chain IDs:D (auth: L)
Chain Length:211
Number of Molecules:1
Biological Source:Mus musculus
Ligand Molecules
CA
MG
Primary Citation
A monoclonal antibody to platelet alpha IIb beta 3 that inhibits protein disulfide isomerase binding and platelet aggregation.
Blood Adv 10 3172 3185 (2026)
PMID: 41779962 DOI: 10.1182/bloodadvances.2025018960
Primary Citation of related structures
11YB
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