ISDA: 11PI

Deposition Date 2026-03-08

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

11PI

Keywords:

LIGASE

Title:

Crystal structure of UFC1 variant Y42F

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.43 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 41 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-fold modifier-conju
Gene (Uniprot):UFC1
Mutagens:Y42F
Chain IDs:A
Chain Length:212
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y3C8

Ligand Molecules

GOL

SO4

Primary Citation

Discovery and Characterization of a Novel Ligand-Binding Site in UFC1 Using Sulfa- and Sulfonate-Based Compounds.

Mulligan, D, Mai, S, Acharya, K, Robustelli, J, Cuttitta, C, Ambroise, R, Tredup, J, Yan, C, Szapiel, N, Yanchunas, J, Newitt, J.A, Mahon, B.P.Show

Biochemistry 65 2940 2954 (2026)

PMID: 42917125 DOI: 10.1021/acs.biochem.5c00701

Primary Citation of related structures

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