11OP image
Deposition Date 2026-03-06
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
11OP
Keywords:
Title:
Crystal Structure of M. tuberculosis ClpP1P2 bound to ONC201
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.11 Å
R-Value Free:
0.24
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
C 1 2 1
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Chain IDs:A, B, C, D, E, F, G
Chain Length:0
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP1
Chain IDs:H, I, J, K, L, M, N
Chain Length:0
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv
Primary Citation
Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.
J.Med.Chem. ? ? ? (2026)
PMID: 42727081 DOI: 10.1021/acs.jmedchem.6c00893
Primary Citation of related structures
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