11OA image
Deposition Date 2026-03-05
Release Date 2026-08-19
Last Version Date 2026-09-02
Entry Detail
PDB ID:
11OA
Keywords:
TRANSFERASE
Title:
Cryo-EM structure of human DNMT3A R882H octadecamer
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
5.04 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
11OA validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA (cytosine-5)-methyltransf
Gene (Uniprot):DNMT3A
Mutagens:R882H
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Chain Length:0
Number of Molecules:18
Biological Source:Homo sapiens
UniProt ID:Q9Y6K1 Pfam ID:PF00855, PF17980, PF21255, PF00145 EC:2.1.1.37
Ligand Molecules
SAH
ZN
Primary Citation
Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant.
Proc.Natl.Acad.Sci.USA 123 e2609226123 e2609226123 (2026)
PMID: 42640801 DOI: 10.1073/pnas.2609226123
Primary Citation of related structures
11OA
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