11MI image
Deposition Date 2026-03-04
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
11MI
Keywords:
Title:
Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP 19
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.65 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.20
Space Group:
C 1 2 1
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Chain IDs:A, B, C, D, E, F, G, O, P, Q, R, S, T, U
Chain Length:0
Number of Molecules:14
Biological Source:Mycobacterium tuberculosis H37Rv
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP1
Chain IDs:H, I, J, K, L, M, N, V, W, X, Y, Z, AA (auth: a), BA (auth: b)
Chain Length:0
Number of Molecules:14
Biological Source:Mycobacterium tuberculosis H37Rv
Primary Citation
Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.
J.Med.Chem. ? ? ? (2026)
PMID: 42727081 DOI: 10.1021/acs.jmedchem.6c00893
Primary Citation of related structures
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