ISDA: 11LZ

Deposition Date 2026-03-04

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

11LZ

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of Interferon alpha2 bound to IFA001 Fab

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.27

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Interferon alpha-2
Gene (Uniprot):IFNA2
Chain IDs:A, B
Chain Length:194
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01563

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:IFA001 Fab light chain
Chain IDs:C, F (auth: L)
Chain Length:216
Number of Molecules:2
Biological Source:Homo sapiens

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:IFA001 Fab heavy chain
Chain IDs:D, E (auth: H)
Chain Length:230
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

NAG

Primary Citation

Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting IFN alpha

Groen, K, Moritz, J.A, Vasquez, S, Rubio, A.A, Kuratli, R, Jones, D, Grafl, D, Motta, M, Fontana, S, Manning, J, Costagli, S, Simonelli, L, Thakur, R, Jarrossay, D, Tran, C, Lee, Y.E, Abela, I.A, Calmy, A, Hirzel, C, Kaufmann, D.E, Swiss HIV Cohort Study,Gunthard, H.F, Kouyos, R.D, Barnes, C.O, Robbiani, D.F, Hale, B.G.Show

Biorxiv ? ? ? (2026)

DOI: 10.64898/2026.10.20.760426

Primary Citation of related structures

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