ISDA: 11LW

Deposition Date 2026-03-03

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

11LW

Keywords:

PROTEIN FIBRIL

Title:

Structure of a tau(297-407)-4D filament grown in potassium citrate buffer for 42 days (polymorph 3)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.40 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Microtubule-associated protei
Gene (Uniprot):MAPT
Mutagens:S396D, S400D, T403D, S404D
Chain IDs:A, B, C, D, E, F, G, H, I, J
Chain Length:111
Number of Molecules:10
Biological Source:Homo sapiens

UniProt ID:P10636

Ligand Molecules

Primary Citation

Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control.

Powell, W.C, Yan, N, Tse, E, Melo, A.A, Vasquez, J.A, Southworth, D.R, Gestwicki, J.E.Show

J.Am.Chem.Soc. 148 35386 35398 (2026)

PMID: 42677560 DOI: 10.1021/jacs.6c04928

Primary Citation of related structures

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