ISDA: 11HK

Deposition Date 2026-02-24

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

11HK

Keywords:

VIRAL PROTEIN

Title:

SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to the VN01H1 Fab (Fab local refinement)

Biological Source:

Source Organism(s):

Saccharomyces cerevisiae S288C (Taxon ID: 559292)
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.70 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E-FICS-v3
Gene (Uniprot):S, SMT3
Chain IDs:A, D, G
Chain Length:605
Number of Molecules:3
Biological Source:Saccharomyces cerevisiae S288C, Severe acute respiratory syndrome coronavirus 2

UniProt ID:Q12306,P0DTC2 Pfam ID:PF00240, PF01601

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Heavy chain of VN01H1 Fab
Chain IDs:B, E, H
Chain Length:226
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:11HK

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Light chain of VN01H1 Fab
Chain IDs:C, F, I
Chain Length:215
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:11HK

Ligand Molecules