ISDA: 11CI

Deposition Date 2026-02-17

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

11CI

Keywords:

HYDROLASE

Title:

Staphylococcus aureus-specific lysin L1-3 (LysM-CHAP) covalently complexed to Pep1a-CMK substrate mimic

Biological Source:

Source Organism(s):

Staphylococcus aureus (Taxon ID: 1280)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.83 Å

R-Value Free:

0.27

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Probable cell wall hydrolase
Chain IDs:A
Chain Length:215
Number of Molecules:1
Biological Source:Staphylococcus aureus

UniProt ID:Q6G9W6

Ligand Molecules

A1DEZ

Primary Citation

Multi-dimensional optimization of a lysin towards a ribolysin against life-threatening S. aureus infections: Fc-LysM-CHAP and its strong synergy with standard of care antibiotics

Badarau, A, Bauer, B, Visram, Z, Qiao, R, Majoros-Hashempour, A, Sollner, J, Durica-Mitic, S, Dunne, O.M, Kluj, R, Kestemont, D, Kieninger, A.K, Kulig, M, Berdaguer, R, Schwebs, T, Zerbs, M, Czermak, P, von Freyberg, M, Schmidt, J, Schmidberger, L, Mayer, D, Protano, M, Miller, H.A, Palowitch, G.M, Dulberger, C.L, Massaro, M, Ivanisenko, N, Jacomet, H, Ngatcha Bakoue, D, Oteri, F, Sela, G, Corsini, L.Show

Biorxiv ? ? ? (2026)

DOI: 10.64898/2026.04.27.720530

Primary Citation of related structures

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