ISDA: 11AI

Deposition Date 2026-02-13

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

11AI

Keywords:

TRANSPORT PROTEIN

Title:

Cryo-EM structure of a bovine CLC-K S68N/R355K chloride channel with inhibitor M-BIM1

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Chloride voltage-gated channe
Gene (Uniprot):CLCNKA
Mutagens:S68N, R355K
Chain IDs:A, B
Chain Length:671
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:E1B792 Pfam ID:PF00654

Ligand Molecules

A1C8M

Primary Citation

Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels

Chien, C.T, Sobecks-Doherty, B.L, Powers, A.S, Das, A, Kreiter, J, Barry, C.N, Chen, M, Hinman, A, Petrakian, C.F, Williams, B, Wood, C.A.P, Xu, M, Dror, R.O, Chiu, W, Maduke, M.Show

Proc.Natl.Acad.Sci.USA 123 ? ? (2026)

DOI: 10.1073/pnas.2605886123

Primary Citation of related structures

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