ISDA: 10OO

Deposition Date 2026-01-29

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

10OO

Keywords:

TRANSFERASE

Title:

FGFR2 mutant D650V with compound 4 (AZD3463)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.85 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fibroblast growth factor rece
Gene (Uniprot):FGFR2
Mutagens:D650V
Chain IDs:A, B
Chain Length:324
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P21802 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1C65

GOL

SO4

Primary Citation

Structure-Based Design of a Novel Covalent 4-(1-Methylindol-3-yl)pyrimidin-2-amine Series Targeting FGFR2 Resistance Mutations.

Hudkins, R.L, Allen, E, Iyer, S, Balcer, A, Neal, M, Ye, Q, Rideout, M, Frye, C.B, Nelson, K.J, Hoffman, I.D, Starrett, J.H, Harris, T, Swanson, R.V, Bensen, D.C.Show

J. Med. Chem. 69 8614 8627 (2026)

PMID: 41913484 DOI: 10.1021/acs.jmedchem.6c00514

Primary Citation of related structures

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