ISDA: 10RC

Deposition Date 2026-02-02

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

10RC

Keywords:

HYDROLASE

Title:

Human SARM1 TIR domain bound to compound 22

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.24

R-Value Work:

0.21

Space Group:

P 2 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NAD(+) hydrolase SARM1
Gene (Uniprot):SARM1
Chain IDs:A, B
Chain Length:143
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q6SZW1 Pfam ID:PF13676

Ligand Molecules

A1C9I

GOL

Primary Citation

Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation.

Albanese, S.K, Hopkins, B.E, Olland, A.M, Fairman, A, Shaikh, N, Feng, S, Thakkar, M, Verras, A, Dementiev, A, Walkup 4th, W.G, Atsriku, C, Srinivas, H.D, Allen, W, Ashraf, K, Bos, P.H, Hsiao, P, Kroeck, K, Liu, Z, Nagarajan, A, Szlenk, C.T, Svensson, M, Johnson, Z.L, Kapilashrami, K, Rubino, S, Kaplan, A, Levinson, A.M.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41948869 DOI: 10.1021/acs.jmedchem.6c00352

Primary Citation of related structures

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