ISDA: 10RA

Deposition Date 2026-02-02

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

10RA

Keywords:

HYDROLASE

Title:

Human SARM1 TIR domain bound to compound 6

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.23

R-Value Work:

0.20

Space Group:

P 21 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sterile alpha and TIR motif-c
Gene (Uniprot):SARM1
Chain IDs:A, B
Chain Length:144
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q6SZW1 Pfam ID:PF13676

Ligand Molecules

A1C9A

Primary Citation

Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation.

Albanese, S.K, Hopkins, B.E, Olland, A.M, Fairman, A, Shaikh, N, Feng, S, Thakkar, M, Verras, A, Dementiev, A, Walkup 4th, W.G, Atsriku, C, Srinivas, H.D, Allen, W, Ashraf, K, Bos, P.H, Hsiao, P, Kroeck, K, Liu, Z, Nagarajan, A, Szlenk, C.T, Svensson, M, Johnson, Z.L, Kapilashrami, K, Rubino, S, Kaplan, A, Levinson, A.M.Show

J. Med. Chem. ? ? ? (2026)

PMID: 41948869 DOI: 10.1021/acs.jmedchem.6c00352

Primary Citation of related structures

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