ISDA: 10PD

Deposition Date 2026-01-30

Release Date 2026-10-07

Last Version Date 2026-10-21

Entry Detail

PDB ID:

10PD

Keywords:

TRANSPORT PROTEIN

Title:

TASK-2 K245A at pH 6.5

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Komagataella pastoris

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.22 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Potassium channel TASK2
Gene (Uniprot):Kcnk5
Chain IDs:A, B
Chain Length:344
Number of Molecules:2
Biological Source:Mus musculus

UniProt ID:Q9JK62 Pfam ID:PF07885

Ligand Molecules

PEE

Primary Citation

Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K + channel TASK-2.

Docter, T, Sorum, B, Li, B, Rietmeijer, R.A, Cook, A.S.I, Kotecha, A, Brohawn, S.G.Show

Proc.Natl.Acad.Sci.USA 123 e2604873123 e2604873123 (2026)

PMID: 42848420 DOI: 10.1073/pnas.2604873123

Primary Citation of related structures

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