ISDA: 10HO

Deposition Date 2026-01-20

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

10HO

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of alkaline nuclease from Herpes simplex virus-1

Biological Source:

Source Organism(s):

Human alphaherpesvirus 1 (Taxon ID: 10298)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.46 Å

R-Value Free:

0.23

R-Value Work:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Deoxyribonuclease
Chain IDs:A
Chain Length:534
Number of Molecules:1
Biological Source:Human alphaherpesvirus 1

Ligand Molecules

ACT

FMT

GOL

SO4

Primary Citation

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity.

Sharma, N, Xie, X, Szczepaniak, R, Rani, C, Khosro, S.K, Krucinska, J, Chen, X, Do, D, Wright, L, Wright, D, Weller, S.Show

Plos Pathog. 22 e1014531 e1014531 (2026)

PMID: 42607086 DOI: 10.1371/journal.ppat.1014531

Primary Citation of related structures

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