10DW image
Deposition Date 2026-01-14
Release Date 2026-08-12
Last Version Date 2026-08-12
Entry Detail
PDB ID:
10DW
Keywords:
TRANSFERASE
Title:
Structure of CRBN/DDB1dB-KAT2A-Compound4 ternary complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli, Trichoplusia ni
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
10DW validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Histone acetyltransferase KAT
Chain IDs:A
Chain Length:331
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Chain IDs:C (auth: B)
Chain Length:859
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Chain IDs:B (auth: C)
Chain Length:485
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
A1C5C
ZN
Primary Citation
Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues.
Science 393 188 194 (2026)
PMID: 42424456 DOI: 10.1126/science.aef5391
Primary Citation of related structures
10DW
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