Search Count: 22
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Identification Of An Imidazopyridine Scaffold To Generate Potent And Selective Tyk2 Inhibitors That Demonstrate Activity In An In Vivo Psoriasis Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.45 Å Release Date: 2017-09-06 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 9ZS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
Ligands: 9ZS
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Identification Of An Imidazopyridine Scaffold To Generate Potent And Selective Tyk2 Inhibitors That Demonstrate Activity In An In Vivo Psoriasis Model
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2017-09-06 Classification: Transferase/Transferase Inhibitor Ligands: 9ZS Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
Ligands: 9ZS
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Human Sod1 C57S Mutant, As-Isolated
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2014-08-27 Classification: OXIDOREDUCTASE Ligands: ZN, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-08-27
Ligands: ZN, SO4
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Human Sod1 C57S Mutant, Metal-Free
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2014-08-27 Classification: OXIDOREDUCTASE Ligands: SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-08-27
Ligands: SO4
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Tyk2 (Jh1) In Complex With Adenosine Di-Phosphate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2013-08-14 Classification: HYDROLASE Ligands: ADP, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-08-14
Ligands: ADP, MG
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Jak2 Kinase (Jh1 Domain) With 2,6-Dichloro-N-(2-Oxo-2,5-Dihydropyridin-4-Yl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X2 Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: 0X2
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Tyk2 Kinase (Jh1 Domain) With 2,6-Dichloro-N-(2-Oxo-2,5-Dihydropyridin-4-Yl)Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SO4, EDO, GOL, 0X2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: SO4, EDO, GOL, 0X2
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: 0X5
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Jak2 Kinase (Jh1 Domain) In Complex With 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-06-19 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X5 Modified Residue(s): PTR |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-06-19
Ligands: 0X5
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-4-Cyano-N-{2-[(Cyclopropylcarbonyl)Amino]Pyridin-4-Yl}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.31 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0X6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0X6
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-N-[2-({[(1R,2R)-2-Fluorocyclopropyl]Carbonyl}Amino)Pyridin-4-Yl]Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0XH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0XH
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Tyk2 (Jh1) In Complex With 2,6-Dichloro-4-Cyano-N-[2-({[(1R,2R)-2-Fluorocyclopropyl]Carbonyl}Amino)Pyridin-4-Yl]Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2013-05-29 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 0XP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: 0XP
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Crystal Structure Of Catechol 2,3-Dioxygenase
Organism: Rhodococcus sp. dk17
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-09-01 Classification: OXIDOREDUCTASE Ligands: FE, CA, GOL Modified Residue(s): MSE |
Organism: Rhodococcus sp. dk17
Method: X-RAY DIFFRACTION
Release Date: 2010-09-01
Ligands: FE, CA, GOL
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Crystal Structure Of Catechol 2,3-Dioxygenase
Organism: Rhodococcus sp. dk17
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2010-09-01 Classification: OXIDOREDUCTASE Ligands: FE, MG, GOL, MBD |
Organism: Rhodococcus sp. dk17
Method: X-RAY DIFFRACTION
Release Date: 2010-09-01
Ligands: FE, MG, GOL, MBD
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Crystal Structure Of The Human Rad9-Hus1-Rad1 Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2009-06-02 Classification: HYDROLASE/CELL CYCLE Modified Residue(s): MSE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-06-02
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Crystal Structure Of The Eif4A-Pdcd4 Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2009-02-24 Classification: HYDROLASE Ligands: EDO, ACY Modified Residue(s): MSE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-02-24
Ligands: EDO, ACY
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Crystal Structure Analysis Of Dppiv Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2008-11-04 Classification: HYDROLASE Ligands: AJH, NAG Modified Residue(s): ASN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-11-04
Ligands: AJH, NAG
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Crystal Structure Of Human Dipeptidyl Peptidase Iv (Dppiv) Complex With Cyclic Hydrazine Derivatives
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2008-01-22 Classification: HYDROLASE Ligands: KR2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-01-22
Ligands: KR2
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Crystal Structure Of Human Dgcr8 Core
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2007-08-21 Classification: RNA BINDING PROTEIN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2007-08-21
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Dcmp Hydroxymethylase From T4 (Phosphate-Bound)
Organism: Enterobacteria phage t4
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 1999-01-13 Classification: TRANSFERASE Ligands: PO4 |
Organism: Enterobacteria phage t4
Method: X-RAY DIFFRACTION
Release Date: 1999-01-13
Ligands: PO4