Search Count: 22
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Discovery Of Mk-8353: An Orally Bioavailable Dual Mechanism Erk Inhibitor For Oncology
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION Resolution:1.45 Å Release Date: 2018-08-08 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SO4, G67 |
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION
Release Date: 2018-08-08
Ligands: SO4, G67
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Discovery Of 3(S)-Thiomethyl Pyrrolidine Erk Inhibitors For Oncology
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2018-05-23 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: SO4, F8V |
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION
Release Date: 2018-05-23
Ligands: SO4, F8V
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Discovery Of An Irreversible Hcv Ns5B Polymerase Inhibitor
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:1.63 Å Release Date: 2013-12-11 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 2F3, PO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2013-12-11
Ligands: 2F3, PO4
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Sar Development And Discovery Of Potent Indole-Based Inhibitors Of The Hepatitis C Virus Ns5B Polymerase
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2012-02-01 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: HI4, PO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2012-02-01
Ligands: HI4, PO4
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Sar Development And Discovery Of Potent Indole-Based Inhibitors Of The Hepatitis C Virus Ns5B Polymerase
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:1.65 Å Release Date: 2012-02-01 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: PO4, HI3 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2012-02-01
Ligands: PO4, HI3
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Novel Hcv Ns5B Polymerase Inhibitors: Discovery Of Indole C2 Acyl Sulfonamides
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:1.77 Å Release Date: 2011-12-07 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 08E, PO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2011-12-07
Ligands: 08E, PO4
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Novel Hcv Ns5B Polymerase Inhibitors: Discovery Of Indole C2 Acyl Sulfonamides
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2011-12-07 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 08F |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2011-12-07
Ligands: 08F
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I. Novel Hcv Ns5B Polymerase Inhibitors: Discovery Of Indole 2- Carboxylic Acids With C3-Heterocycles
Organism: Hepatitis c virus isolate hc-j4
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2011-08-31 Classification: transferase/transferase INHIBITOR Ligands: PO4, 053 |
Organism: Hepatitis c virus isolate hc-j4
Method: X-RAY DIFFRACTION
Release Date: 2011-08-31
Ligands: PO4, 053
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I. Novel Hcv Ns5B Polymerase Inhibitors: Discovery Of Indole 2- Carboxylic Acids With C3-Heterocycles
Organism: Hepatitis c virus isolate hc-j4
Method: X-RAY DIFFRACTION Resolution:1.97 Å Release Date: 2011-08-31 Classification: transferase/transferase INHIBITOR Ligands: PO4, 054 |
Organism: Hepatitis c virus isolate hc-j4
Method: X-RAY DIFFRACTION
Release Date: 2011-08-31
Ligands: PO4, 054
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I. Novel Hcv Ns5B Polymerase Inhibitors: Discovery Of Indole 2- Carboxylic Acids With C3-Heterocycles
Organism: Hepatitis c virus isolate hc-j4
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2011-08-31 Classification: transferase/transferase INHIBITOR Ligands: 058 |
Organism: Hepatitis c virus isolate hc-j4
Method: X-RAY DIFFRACTION
Release Date: 2011-08-31
Ligands: 058
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Crystal Structure Of Catalytic Domain Of Tace With 2-(2-Aminothiazol-4-Yl)Pyrrolidine-Based Tartrate Diamides
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.88 Å Release Date: 2011-04-20 Classification: hydrolase/hydrolase inhibitor Ligands: IPA, INN, ZN, CA, 786 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-04-20
Ligands: IPA, INN, ZN, CA, 786
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Hcv Ns3-4A Protease Domain With Ketoamide Inhibitor Narlaprevir
Organism: Hepatitis c virus subtype 1a
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2011-01-19 Classification: VIRAL PROTEIN/INHIBITOR Ligands: ZN, NNA, BME |
Organism: Hepatitis c virus subtype 1a
Method: X-RAY DIFFRACTION
Release Date: 2011-01-19
Ligands: ZN, NNA, BME
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Crystal Structure Of The Catalytic Domain Of Tace With Indazolinone-Phenyl-Hydantoin Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2010-12-08 Classification: HYDROLASE Ligands: ZN, 727, IPA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-12-08
Ligands: ZN, 727, IPA
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Crystal Structure Of The Catalytic Domain Of Tace With Isoindolinone-Biphenyl-Hydantoin Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2010-12-08 Classification: HYDROLASE Ligands: Z93, ZN, IPA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-12-08
Ligands: Z93, ZN, IPA
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Hcv Ns3 Protease Domain With P1-P3 Macrocyclic Ketoamide Inhibitor
Organism: Hepatitis c virus subtype 1a
Method: X-RAY DIFFRACTION Resolution:2.65 Å Release Date: 2010-10-27 Classification: VIRAL PROTEIN Ligands: ZN, JZT, BME |
Organism: Hepatitis c virus subtype 1a
Method: X-RAY DIFFRACTION
Release Date: 2010-10-27
Ligands: ZN, JZT, BME
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Crystal Structure Of Catalytic Domain Of Tace With Benzimidazolyl-Thienyl-Tartrate Based Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2010-07-28 Classification: HYDROLASE Ligands: ZN, 50X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-07-28
Ligands: ZN, 50X
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Aurora A Kinase Complexed With Sch 1473759
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2010-07-21 Classification: TRANSFERASE Ligands: PG4, EML |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-07-21
Ligands: PG4, EML
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Crystal Structure Of Catalytic Domain Of Tace With Hydantoin Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.92 Å Release Date: 2010-03-02 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZN, INN, IPA, Z94 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-03-02
Ligands: ZN, INN, IPA, Z94
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Crystal Structure Of Catalytic Domain Of Tace With The First Hydantoin Inhibitor Occupying The S1' Pocket
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.75 Å Release Date: 2010-03-02 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZN, 724 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-03-02
Ligands: ZN, 724
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Crystal Structure Of Catalytic Domain Of Tace With Tartrate-Based Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2009-12-22 Classification: HYDROLASE Ligands: ZN, INN, 403 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-12-22
Ligands: ZN, INN, 403