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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.84 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, ANP |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, CL, EDO |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL1, EDO, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.58 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL2, EDO |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL3 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL4, A1BL5, SO4, CL, EDO |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.63 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL0, CL, EDO, DMS |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL6, EDO, GOL, DMS |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL7, EDO, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL8, EDO |
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Crystal Structure Of Holo-Plygrcs, A Bacteriophage Endolysin In Complex With Cold Shock Protein C
Organism: Staphylococcus phage grcs, Escherichia coli k-12
Method: X-RAY DIFFRACTION Resolution:1.67 Å Release Date: 2025-01-01 Classification: ANTIMICROBIAL PROTEIN Ligands: MES |
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Crystal Structure Of Plygrcs, A Bacteriophage Endolysin In Complex With Cold Shock Protein C
Organism: Staphylococcus phage grcs, Escherichia coli k-12
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2023-10-18 Classification: ANTIMICROBIAL PROTEIN Ligands: CA, MES |
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Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION Resolution:1.01 Å Release Date: 2023-05-24 Classification: HYDROLASE Ligands: ZN, OKC |
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Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION Resolution:1.11 Å Release Date: 2023-05-24 Classification: HYDROLASE Ligands: ZN, OK0 |
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Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION Resolution:1.02 Å Release Date: 2023-05-24 Classification: HYDROLASE Ligands: MG, ZN, OJR |