Search Count: 40
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-04-01
Ligands: MES, A1C6X, NAG
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: A1C6O
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C6Q, NAG
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C6Z, NAG
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C7M
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Crystal Structure Of Wrn Helicase With Bound Amppnp
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.84 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, ANP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, ANP
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Crystal Structure Of Apo Wrn Helicase In Form D
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, CL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, CL, EDO
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Crystal Structure Of Wrn Helicase With Allosteric Fragment 1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL1, EDO, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL1, EDO, CL
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Crystal Structure Of Wrn Helicase With Bound Allosteric Fragment 2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.58 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL2, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL2, EDO
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Crystal Structure Of Wrn Helicase With Bound Allosteric Fragment 3.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL3
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Crystal Structure Of Wrn Helicase With Bound Allosteric Fragment 4
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL4, A1BL5, SO4, CL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL4, A1BL5, SO4, CL, EDO
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Crystal Structure Of Wrn Helicase With Bound Allosteric Compound 1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.63 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL0, CL, EDO, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL0, CL, EDO, DMS
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Crystal Structure Of Wrn Helicase With Bound Allosteric Compound 3
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL6, EDO, GOL, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL6, EDO, GOL, DMS
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Crystal Structure Of Wrn Helicase With Bound Allosteric Compound 5
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL7, EDO, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL7, EDO, CL
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Crystal Structure Of Wrn Helicase With Bound Compound 6
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2026-01-14 Classification: HYDROLASE Ligands: ZN, A1BL8, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-01-14
Ligands: ZN, A1BL8, EDO
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Crystal Structure Of Holo-Plygrcs, A Bacteriophage Endolysin In Complex With Cold Shock Protein C
Organism: Staphylococcus phage grcs, Escherichia coli k-12
Method: X-RAY DIFFRACTION Resolution:1.67 Å Release Date: 2025-01-01 Classification: ANTIMICROBIAL PROTEIN Ligands: MES |
Organism: Staphylococcus phage grcs, Escherichia coli k-12
Method: X-RAY DIFFRACTION
Release Date: 2025-01-01
Ligands: MES
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Crystal Structure Of Plygrcs, A Bacteriophage Endolysin In Complex With Cold Shock Protein C
Organism: Staphylococcus phage grcs, Escherichia coli k-12
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2023-10-18 Classification: ANTIMICROBIAL PROTEIN Ligands: CA, MES |
Organism: Staphylococcus phage grcs, Escherichia coli k-12
Method: X-RAY DIFFRACTION
Release Date: 2023-10-18
Ligands: CA, MES
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Inhibitor Bound Vim1
Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION Resolution:1.01 Å Release Date: 2023-05-24 Classification: HYDROLASE Ligands: ZN, OKC |
Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION
Release Date: 2023-05-24
Ligands: ZN, OKC
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Inhibitor Bound Vim1
Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION Resolution:1.11 Å Release Date: 2023-05-24 Classification: HYDROLASE Ligands: ZN, OK0 |
Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION
Release Date: 2023-05-24
Ligands: ZN, OK0
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Inhibitor Bound Vim1
Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION Resolution:1.02 Å Release Date: 2023-05-24 Classification: HYDROLASE Ligands: MG, ZN, OJR |
Organism: Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION
Release Date: 2023-05-24
Ligands: MG, ZN, OJR