Search Count: 27
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Potent Long-Acting Inhibitors Targeting Hiv-1 Capsid Based On A Versatile Quinazolin-4-One Scaffold
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2023-02-15 Classification: ANTIVIRAL-PROTEIN/INHIBITOR Ligands: EDO, Y05 |
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION
Release Date: 2023-02-15
Ligands: EDO, Y05
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Crystal Structure Of Hiv-1 Integrase Complexed With (2S)-2-(Tert-Butoxy)-2-(5-{2-[(2-Chloro-6-M Ethylphenyl)Methyl]-1,2,3,4-Tetrahydroisoquinolin-6-Yl}-4- (4,4-Dimethylpiperidin-1-Yl)-2-Methylpyridin-3-Yl)Acetic Acid
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2022-07-06 Classification: TRANSFERASE Ligands: O20, SO4 |
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION
Release Date: 2022-07-06
Ligands: O20, SO4
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Crystal Structure Of Hiv-1 Integrase Complexed With Compound-2A Aka (2S)-2-(Tert-Butoxy)-2-[7-(4,4-Dimethylpipe Ridin-1-Yl)-8-{4-[2-(4-Fluorophenyl)Ethoxy]Phenyl}-2,5-Dim Ethylimidazo[1,2-A]Pyridin-6-Yl]Acetic Acid
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION Resolution:1.84 Å Release Date: 2022-06-08 Classification: DNA BINDING PROTEIN, viral protein Ligands: KZD, SO4 |
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION
Release Date: 2022-06-08
Ligands: KZD, SO4
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Hiv Integrase In Complex With Compound-15
Organism: human immunodeficiency virus 1
Method: X-RAY DIFFRACTION Resolution:2.53 Å Release Date: 2022-04-06 Classification: DNA BINDING PROTEIN, Viral protein Ligands: MG, GE7 |
Organism: human immunodeficiency virus 1
Method: X-RAY DIFFRACTION
Release Date: 2022-04-06
Ligands: MG, GE7
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Hiv Integrase In Complex With Compound-25
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2022-04-06 Classification: DNA BINDING PROTEIN, Viral Protein Ligands: SO4, GEI, GOL |
Organism: Human immunodeficiency virus 1
Method: X-RAY DIFFRACTION
Release Date: 2022-04-06
Ligands: SO4, GEI, GOL
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Crystal Structure Of The Hepatitis C Virus Genotype 2A Strain Jfh1 Ns5B Rna-Dependent Rna Polymerase In Complex With 6-[Ethyl(Methylsulfonyl)Amino]-2-(4-Fluorophenyl)-N-Methyl-5-(3-{[1-(Pyrimidin-2-Yl)Cyclopropyl]Carbamoyl}Phenyl)-1-Benzofuran-3-Carboxamide
Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:2.08 Å Release Date: 2018-11-21 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: J6D, SCN, 2PE, GOL |
Organism: Hepacivirus c
Method: X-RAY DIFFRACTION
Release Date: 2018-11-21
Ligands: J6D, SCN, 2PE, GOL
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Crystal Structure Of The Hepatitis C Virus Genotype 2A Strain Jfh1 L30S Ns5B Rna-Dependent Rna Polymerase In Complex With 6-(Ethylamino)-2-(4-Fluorophenyl)-5-(3-{[1-(5-Fluoropyrimidin-2-Yl)Cyclopropyl]Carbamoyl}-4-Methoxyphenyl)-N-Methyl-1-Benzofuran-3-Carboxamide
Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:2.17 Å Release Date: 2018-11-21 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: J6J, SO4, GOL, PG4 |
Organism: Hepacivirus c
Method: X-RAY DIFFRACTION
Release Date: 2018-11-21
Ligands: J6J, SO4, GOL, PG4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 2-(4-Fluorophenyl)-N-Methyl-6-[(Methylsulfonyl)Amino]-5-(Propan-2-Yloxy)-1-Benzofuran-3-Carboxamide
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2017-05-10 Classification: TRANSFERASE Ligands: 23E, 2N5, SO4, GOL, PG4 |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 23E, 2N5, SO4, GOL, PG4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 2-({3-[1-(2-Cyclopropylethyl)-6-Fluoro-4-Hydroxy-2-Oxo-1,2-Dihydroquinolin-3-Yl]-1,1-Dioxo-1,4-Dihydro-1Lambda~6~,2,4-Benzothiadiazin-7-Yl}Oxy)Acetamide
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:2.06 Å Release Date: 2017-05-10 Classification: TRANSFERASE Ligands: 23E, 8XV, SO4 |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 23E, 8XV, SO4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 3-[2-(4-Fluorophenyl)-3-(Methylcarbamoyl)-1-Benzofuran-5-Yl]Benzoic Acid
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:2.54 Å Release Date: 2017-05-10 Classification: TRANSFERASE Ligands: 23E, SO4, 8XS, GOL |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 23E, SO4, 8XS, GOL
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 5-[3-(Tert-Butylcarbamoyl)Phenyl]-2-(4-Fluorophenyl)-N-Methyl-1-Benzofuran-3-Carboxamide
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:2.25 Å Release Date: 2017-05-10 Classification: TRANSFERASE Ligands: 23E, 8XP, SO4, GOL |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 23E, 8XP, SO4, GOL
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase C316N In Complex With 2-(4-Fluorophenyl)-N-Methyl-5-[3-({2-Methyl-1-Oxo-1-[(1,3,4-Thiadiazol-2-Yl)Amino]Propan-2-Yl}Carbamoyl)Phenyl]-1-Benzofuran-3-Carboxamide
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2017-05-10 Classification: TRANSFERASE Ligands: 23E, 8XM, SO4, GOL |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 23E, 8XM, SO4, GOL
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 4-Fluoro-2-(4-Fluorophenyl)-N-Methyl-5-(2-Methyl-5-{[1-(Pyrimidin-2-Yl)Cyclopropyl]Carbamoyl}Phenyl)-1-Benzofuran-3-Carboxamide (Bms-929075)
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:2.95 Å Release Date: 2017-05-10 Classification: TRANSFERASE Ligands: 23E, 8XJ, SO4, GOL |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 23E, 8XJ, SO4, GOL
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Crystal Structure Of The Hepatitis C Virus Genotype 2A Strain Jfh1 L30S Ns5B Rna-Dependent Rna Polymerase In Complex With 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6-(Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3-Carboxamide
Organism: Hepatitis c virus genotype 2a (isolate jfh-1)
Method: X-RAY DIFFRACTION Resolution:1.97 Å Release Date: 2017-03-15 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: 7NG, SO4, PE5, PG4 |
Organism: Hepatitis c virus genotype 2a (isolate jfh-1)
Method: X-RAY DIFFRACTION
Release Date: 2017-03-15
Ligands: 7NG, SO4, PE5, PG4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna- Dependent Rna Polymerase In Complex With 5-[3-(Tert-Butylcarbamoyl)Phenyl]-6-(Ethylamino)-2-(4-Fluorophenyl)-N-Methylfuro[2,3-B]Pyridine-3-Carboxamide
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION Resolution:3.04 Å Release Date: 2017-03-15 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: 23E, SO4, 7NG |
Organism: Hepatitis c virus genotype 1b (isolate con1)
Method: X-RAY DIFFRACTION
Release Date: 2017-03-15
Ligands: 23E, SO4, 7NG
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 2-[(Benzenecarbonyl)Amino]-3-[(4-Chlorophenyl)Methoxy]Benzoic Acid
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2016-11-30 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: 23E, 7HL, SO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2016-11-30
Ligands: 23E, 7HL, SO4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 3-[(4-Chlorophenyl)Methoxy]-2-(1-Oxo-1,3-Dihydro-2H-Isoindol-2-Yl)Benzoic Acid
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2016-11-30 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: 23E, 7HM, SO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2016-11-30
Ligands: 23E, 7HM, SO4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase In Complex With 2-{[2-(Carboxymethoxy)Benzene-1-Carbonyl]Amino}-3-[(4-Chlorophenyl)Methoxy]Benzoic Acid
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:2.57 Å Release Date: 2016-11-30 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: 23E, 7HO, SO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2016-11-30
Ligands: 23E, 7HO, SO4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna- Dependent Rna Polymerase In Complex With N-{3-[(Benzenecarbonyl)Amino]-4-[(4-Chlorophenyl)Methoxy]Benzene-1-Carbonyl}Glycine
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:2.06 Å Release Date: 2016-11-30 Classification: TRANSFERASE/TRANSFERASE inhibitor Ligands: 23E, 7HH, SO4 |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2016-11-30
Ligands: 23E, 7HH, SO4
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Crystal Structure Of The Hepatitis C Virus Ns5B Rna-Dependent Rna Polymerase Complex With Bms-791325 Also Known As (1Ar,12Bs)-8-Cyclohexyl-N-(Dimethylsulfamoyl)-11-Methoxy-1A-{[(1R,5S)-3-Methyl-3,8-Diazabicyclo[3.2.1]Oct-8-Yl]Carbonyl}-1,1A,2,12B-Tetrahydrocyclopropa[D]Indolo[2,1-A][2]Benzazepine-5-Carboxamide And 2-(4-Fluorophenyl)-N-Methyl-6-[(Methylsulfonyl)Amino]-5-(Propan-2-Yloxy)-1-Benzofuran-3-Carboxamide
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION Resolution:2.75 Å Release Date: 2014-03-19 Classification: transferase/transferase INHIBITOR Ligands: 2N7, 2N5, SO4, BOG |
Organism: Hepatitis c virus
Method: X-RAY DIFFRACTION
Release Date: 2014-03-19
Ligands: 2N7, 2N5, SO4, BOG