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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
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Development Of A Novel Tricyclic Class Of Potent And Selective Fixa Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.84 Å Release Date: 2015-11-18 Classification: HYDROLASE/HYDROLASE INHIBITOR |
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Thrombin In Complex With (S)-(4-Chloro-2-((1-(5-Methyl-1H-Pyrrole-2-Carbonyl)Pyrrolidine-2-Carboxamido)Methyl)Phenyl)Methanaminium
Organism: Homo sapiens, Hirudo medicinalis
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2015-06-17 Classification: Hydrolase/Hydrolase Inhibitor Ligands: MG, GOL, NAG, 45S |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.86 Å Release Date: 2015-06-03 Classification: Hydrolase/Hydrolase Inhibitor Ligands: 4M1, NA, NHE |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.41 Å Release Date: 2015-05-20 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 4K6, NA, NHE, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.41 Å Release Date: 2015-05-20 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 4LN, NA, NHE, CL |