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Structure Of Kras-G12C Bound To 1-[(4Ar,10P,13R)-10-[5-Amino-4-Fluoro-3-Methyl-2-(Trifluoromethyl)Phenyl]-11-Chloro-9-Fluoro-1,2,4A,5-Tetrahydropyrazino[1',2':4,5][1,4]Oxazino[2,3-C]Quinolin-3(4H)-Yl]Prop-2-En-1-One (Compound 15)
Organism: Homo sapiens, Synthetic construct
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2026-03-11 Classification: ONCOPROTEIN Ligands: MG, GDP, A1CII, PEG, GOL, DMS, ACT |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.84 Å Release Date: 2026-03-11 Classification: ONCOPROTEIN Ligands: A1CQ2, GDP, MG |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.17 Å Release Date: 2026-03-11 Classification: ONCOPROTEIN Ligands: GDP, MG, DMS, EDO, A1AWR, PEG |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.17 Å Release Date: 2024-01-17 Classification: GENE REGULATION Ligands: PO4, GOL, VLH, CL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.19 Å Release Date: 2024-01-17 Classification: LIGASE Ligands: VL6 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.57 Å Release Date: 2024-01-17 Classification: GENE REGULATION Ligands: ZN, VLC, CL |
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Identification Of Gdc-1971 (Rly-1971), A Shp2 Inhibitor Designed For The Treatment Of Solid Tumors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2023-10-11 Classification: HYDROLASE Ligands: SO4, YR2 |
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Identification Of Gdc-1971 (Rly-1971), A Shp2 Inhibitor Designed For The Treatment Of Solid Tumors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.84 Å Release Date: 2023-10-11 Classification: HYDROLASE Ligands: SO4, YT2 |
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Identification Of Gdc-1971 (Rly-1971), A Shp2 Inhibitor Designed For The Treatment Of Solid Tumors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2023-10-11 Classification: HYDROLASE Ligands: ZH5 |
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Identification Of Gdc-1971 (Rly-1971), A Shp2 Inhibitor Designed For The Treatment Of Solid Tumors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.27 Å Release Date: 2023-10-11 Classification: HYDROLASE/INHIBITOR Ligands: ZJX |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2022-08-31 Classification: HYDROLASE/INHIBITOR Ligands: EDO, ZN, ZJP, SO4 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.96 Å Release Date: 2022-03-16 Classification: HYDROLASE/Immune System Ligands: Z07, GDP, MG, ACT, CAD, P15, EDO, DMS |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZN, ZJG, EDO, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZN, EDO, ZKA, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:2.11 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZN, ZJJ, EDO, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.65 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZN, ZKJ, EDO, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.99 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZJG, EDO, ZN, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZN, ZKA, EDO, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZN, ZJJ, EDO, SO4 |
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Organism: Hepacivirus c
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: ZKJ, ZN, SO4 |