ISDA: 9ZB1

Deposition Date 2025-11-19

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9ZB1

Keywords:

TRANSFERASE

Title:

Crystal structure of human MGAT1 in complex with UDP-GlcNAc.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.21

R-Value Work:

0.16

R-Value Observed:

0.17

Space Group:

P 2 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-1,3-mannosyl-glycoprote
Gene (Uniprot):MGAT1
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P26572 Pfam ID:PF03071 EC:2.4.1.101

Ligand Molecules

UD1

Primary Citation

Genetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer.

Vassallo, K.M, Chen, Y.P, Handing, K.B, Lu, A.Z, Meier, S.R, Liu, S, Shen, B, Teng, T, Yu, Y, Ji, L, Lazarides, K, Huang, A, Min, C, Haines, B.B, Mallender, W.D, Sun, S, Liu, M.S, Amor, A.J, Whittington, D.A, Salerno, R, Bruzzese, F.J, Maxwell, J.P, Maynard, A, McCarren, P, Come, J.H, Throner, S, Andersen, J.N, Zhang, W, Gueroussov, S.Show

J.Biol.Chem. ? 113551 113551 (2026)

PMID: 42727848 DOI: 10.1016/j.jbc.2026.113551

Primary Citation of related structures

Feedback Form