ISDA: 9ZYT

Deposition Date 2026-01-06

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9ZYT

Keywords:

GENE REGULATION

Title:

Crystal Structure of BRD4 Bromodomain BD1 in Complex with Small Molecule PLX-3618

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.66 Å

R-Value Free:

0.20

R-Value Work:

0.15

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD4
Chain IDs:A (auth: AAA), B (auth: BBB)
Chain Length:124
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O60885 Pfam ID:PF00439

Ligand Molecules

A1C4W

EDO

Primary Citation

Discovery and Structural Optimization of BRD4-Selective Monovalent Direct Degraders

Leriche, G, Barmare, F, Toth, J.I, Jamborcic, A, Kampert, T.L, Steadman, K, Yang, L, Fish, S, Daniele, E, McCarrick, M, Kallel, E.A, Li, X, Thompson, P.A, Parker, G.S, Freeman-Cook, K, Bailey, S.Show

Acs Med.Chem.Lett. ? ? ? (2026)

DOI: 10.1021/acsmedchemlett.6c00022

Primary Citation of related structures

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