9ZY1 image
Deposition Date 2026-01-05
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
9ZY1
Keywords:
ANTIVIRAL PROTEIN/RNA
Title:
Cryo-EM structure of the dimeric HIV-2 Vif-human APOBEC3H-CBFbeta complex
Biological Source:
Source Organism(s):
Human immunodeficiency virus 2 (Taxon ID: 11709)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZY1 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Virion infectivity factor
Chain IDs:A (auth: 1), D (auth: A)
Chain Length:215
Number of Molecules:2
Biological Source:Human immunodeficiency virus 2
UniProt ID:Q9YTT9
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Core-binding factor subunit b
Gene (Uniprot):CBFB
Chain IDs:B (auth: 2), E (auth: B)
Chain Length:182
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q13951 Pfam ID:PF02312
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Single-stranded DNA cytosine
Gene (Uniprot):APOBEC3H
Chain IDs:C (auth: 3), F (auth: C)
Chain Length:183
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:B7TQM6 EC:3.5.4.38
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*UP*UP*UP*UP*UP*UP
Chain IDs:G (auth: D)
Chain Length:8
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*AP*AP*AP*AP*AP*AP
Chain IDs:H (auth: E)
Chain Length:8
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
ZN
Primary Citation
The structural mechanism of HIV-2 Vif antagonism of human APOBEC3H.
Nat Commun ? ? ? (2026)
PMID: 42373647 DOI: 10.1038/s41467-026-75045-1
Primary Citation of related structures
9ZY1
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