9ZWS image
Deposition Date 2026-01-03
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
9ZWS
Keywords:
TRANSFERASE
Title:
Crystal structure of the N4BP2 polynucleotide kinase domain complexed with ATP or ADP, Mg, and the trinucleotide substrate ACA or its 5'-phosphorylated product pACA.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
I 2 2 2
9ZWS validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:NEDD4-binding protein 2
Gene (Uniprot):N4BP2
Chain IDs:A, B, C
Chain Length:182
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q86UW6 Pfam ID:PF13671 EC:3.-.-.-
Polymer Type:polyribonucleotide
Molecule:5'-OH RNA (5'-r(ApCpA)-3') or
Chain IDs:D, E, F
Chain Length:3
Number of Molecules:3
Biological Source:synthetic construct
Ligand Molecules
ADP
ATP
MG
SO4
Primary Citation
Structure, Specificity, and Catalytic Mechanism of the Polynucleotide Kinase Domains from the Human N4BP2 Kinase Family
Nat Commun ? ? ? (2026)
Primary Citation of related structures
9ZWS
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