ISDA: 9ZS0

Deposition Date 2025-12-22

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9ZS0

Keywords:

OXIDOREDUCTASE

Title:

Human malic enzyme 2 complex with FLA at 2 Angstrom.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.21

R-Value Work:

0.20

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:NAD-dependent malic enzyme, m
Chain IDs:A, B
Chain Length:575
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1C34

EDO

NAD

Primary Citation

A cryptic allosteric pocket shapes isoform-selective inhibition of human malic enzymes.

Krinkel, B.A, Yosaatmadja, Y, Slayton, M.D, Krinkel, A, Copping, J, Jeon, J.H, Eu, J, Kohagen, K, Ashoorzadeh, A, Smaill, J, Flanagan, J, Walker, C, Merajver, S.D, Loomes, K, Squire, C.J.Show

Protein Sci. 35 e70757 e70757 (2026)

PMID: 42581399 DOI: 10.1002/pro.70757

Primary Citation of related structures

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