9ZRG image
Deposition Date 2025-12-19
Release Date 2026-02-18
Last Version Date 2026-02-18
Entry Detail
PDB ID:
9ZRG
Keywords:
RIBOSOME
Title:
Structure of naked mole-rat ribosome (non-rotated)
Biological Source:
Source Organism(s):
Heterocephalus glaber (Taxon ID: 10181)
Expression System(s):
Heterocephalus glaber
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZRG validation report missing
Macromolecular Entities
Polymer Type:polyribonucleotide
Molecule:28S ribosomal RNA
Chain IDs:ZB (auth: A5), DC (auth: A6)
Chain Length:3889
Number of Molecules:2
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:5S ribosomal RNA
Chain IDs:AC (auth: A7)
Chain Length:121
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:5.8S ribosomal RNA
Chain IDs:BC (auth: A8)
Chain Length:157
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPSA
Chain IDs:F (auth: AA)
Chain Length:208
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6K1L6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS3A
Chain IDs:E (auth: AB)
Chain Length:215
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C1K3 Pfam ID:PF01015
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S2
Chain IDs:N (auth: AC)
Chain Length:226
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3
Chain IDs:GA (auth: AD)
Chain Length:227
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S4, X i
Chain IDs:M (auth: AE)
Chain Length:263
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps5
Chain IDs:IA (auth: AF)
Chain Length:191
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B7K7 Pfam ID:PF00177
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6
Chain IDs:O (auth: AG)
Chain Length:237
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J125
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S7
Gene (Uniprot):Rps7
Chain IDs:P (auth: AH)
Chain Length:190
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C7L2 Pfam ID:PF01251
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Chain IDs:R (auth: AI)
Chain Length:206
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps9
Chain IDs:L (auth: AJ)
Chain Length:182
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5CBG2 Pfam ID:PF00163, PF01479
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS10
Chain IDs:X (auth: AK)
Chain Length:98
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6IZJ7
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS11
Chain IDs:D (auth: AL)
Chain Length:158
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J0Q6
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Chain IDs:Y (auth: AM)
Chain Length:124
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps13
Chain IDs:C (auth: AN)
Chain Length:150
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B0I4 Pfam ID:PF08069, PF00312
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S14
Chain IDs:A (auth: AO)
Chain Length:136
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15
Chain IDs:CA (auth: AP)
Chain Length:127
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS16
Chain IDs:JA (auth: AQ)
Chain Length:141
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BJD7 Pfam ID:PF00380
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS17
Chain IDs:BA (auth: AR)
Chain Length:126
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B1R5 Pfam ID:PF00833
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS18
Chain IDs:Z (auth: AS)
Chain Length:137
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0N8ESM4
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps19
Chain IDs:DA (auth: AT)
Chain Length:141
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AZQ1 Pfam ID:PF01090
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S20
Chain IDs:W (auth: AU)
Chain Length:104
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S21
Gene (Uniprot):Rps21
Chain IDs:G (auth: AV)
Chain Length:82
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C8F1 Pfam ID:PF01249
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS15A
Chain IDs:Q (auth: AW)
Chain Length:129
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AY31 Pfam ID:PF00410
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS23
Chain IDs:B (auth: AX)
Chain Length:142
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J0V6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):Rps24
Chain IDs:H (auth: AY)
Chain Length:126
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6T3G5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25
Chain IDs:EA (auth: AZ)
Chain Length:75
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J730
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S26
Chain IDs:I (auth: Aa)
Chain Length:107
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):Rps27
Chain IDs:J (auth: Ab)
Chain Length:84
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:E3VX74 Pfam ID:PF01667
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S28
Chain IDs:FA (auth: Ac)
Chain Length:64
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS29
Chain IDs:AA (auth: Ad)
Chain Length:53
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6JEN2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like protein FUBI
Gene (Uniprot):Fau
Chain IDs:K (auth: Ae)
Chain Length:59
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B6L6 Pfam ID:PF04758
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):Rps27a
Chain IDs:HA (auth: Af)
Chain Length:71
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B8W4 Pfam ID:PF01599
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):GNB2L1
Chain IDs:V (auth: Ag)
Chain Length:313
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J231
Polymer Type:polyribonucleotide
Molecule:18S ribosomal RNA
Chain IDs:S (auth: B2)
Chain Length:1861
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:E-tRNA
Chain IDs:CC (auth: BC)
Chain Length:75
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL8
Chain IDs:UA (auth: CA)
Chain Length:255
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J3A4
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Chain IDs:FB (auth: CB)
Chain Length:397
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L4
Chain IDs:QB (auth: CC)
Chain Length:368
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L5
Chain IDs:SA (auth: CD)
Chain Length:289
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L6
Chain IDs:XB (auth: CE)
Chain Length:262
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L7
Chain IDs:GB (auth: CF)
Chain Length:229
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L7a
Chain IDs:YB (auth: CG)
Chain Length:246
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L9
Chain IDs:WB (auth: CH)
Chain Length:191
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L10-lik
Chain IDs:RA (auth: CI)
Chain Length:213
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl11
Chain IDs:VB (auth: CJ)
Chain Length:168
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6TFX7
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L13
Chain IDs:MA (auth: CL)
Chain Length:210
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L14
Chain IDs:OA (auth: CM)
Chain Length:139
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L15
Gene (Uniprot):Rpl15
Chain IDs:QA (auth: CN)
Chain Length:203
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BFP9 Pfam ID:PF00827
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L13a
Chain IDs:LA (auth: CO)
Chain Length:202
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L17
Chain IDs:XA (auth: CP)
Chain Length:152
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L18
Chain IDs:TA (auth: CQ)
Chain Length:188
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L19
Chain IDs:T (auth: CR)
Chain Length:153
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L18a
Chain IDs:VA (auth: CS)
Chain Length:175
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL21
Chain IDs:WA (auth: CT)
Chain Length:159
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5ATV5 Pfam ID:PF01157
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):GW7_09159
Chain IDs:YA (auth: CU)
Chain Length:112
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C569 Pfam ID:PF01776
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl23
Chain IDs:NA (auth: CV)
Chain Length:133
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BK67 Pfam ID:PF00238
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl24
Chain IDs:U (auth: CW)
Chain Length:124
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C020 Pfam ID:PF01246
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):GW7_08185
Chain IDs:ZA (auth: CX)
Chain Length:121
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BVI3 Pfam ID:PF03939, PF00276
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L26
Chain IDs:AB (auth: CY)
Chain Length:133
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27
Gene (Uniprot):RPL27
Chain IDs:BB (auth: CZ)
Chain Length:135
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BN91 Pfam ID:PF00467, PF01777
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27a
Chain IDs:PA (auth: Ca)
Chain Length:147
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):GW7_07753
Chain IDs:EB (auth: Cb)
Chain Length:78
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AXN2 Pfam ID:PF01779
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L30
Chain IDs:HB (auth: Cc)
Chain Length:100
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL31
Chain IDs:IB (auth: Cd)
Chain Length:113
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0N8ESF6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L32
Gene (Uniprot):Rpl32
Chain IDs:JB (auth: Ce)
Chain Length:133
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BYD8 Pfam ID:PF01655
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35a
Chain IDs:KB (auth: Cf)
Chain Length:109
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl34
Chain IDs:LB (auth: Cg)
Chain Length:114
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AQL2 Pfam ID:PF01199
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35
Chain IDs:DB (auth: Ch)
Chain Length:123
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36
Gene (Uniprot):Rpl36
Chain IDs:MB (auth: Ci)
Chain Length:103
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C0Q6 Pfam ID:PF01158
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L37
Gene (Uniprot):RPL37
Chain IDs:NB (auth: Cj)
Chain Length:90
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6JT91
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL38
Chain IDs:OB (auth: Ck)
Chain Length:69
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6IYP5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):LOC101707773
Chain IDs:PB (auth: Cl)
Chain Length:50
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6NYH3
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):Uba52
Chain IDs:RB (auth: Cm)
Chain Length:52
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C5A6 Pfam ID:PF01020
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L41
Gene (Uniprot):RPL41
Chain IDs:SB (auth: Cn)
Chain Length:25
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J950
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36a
Gene (Uniprot):Rpl36al
Chain IDs:UB (auth: Co)
Chain Length:105
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BW65 Pfam ID:PF00935
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl37a
Chain IDs:TB (auth: Cp)
Chain Length:90
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:E3VX70 Pfam ID:PF01780
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L28
Chain IDs:CB (auth: Cr)
Chain Length:137
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L10a
Chain IDs:KA (auth: Cz)
Chain Length:217
Number of Molecules:1
Biological Source:Heterocephalus glaber
Ligand Molecules
NA
Primary Citation
Structures of naked mole-rat, tuco-tuco, and guinea pig ribosomes-is rRNA fragmentation linked to translational fidelity?
Nucleic Acids Res. 54 ? ? (2026)
PMID: 41603730 DOI: 10.1093/nar/gkag006

Abstact

Ribosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, display fragmented 28S ribosomal RNA (rRNA), coupled with high translational fidelity and long lifespan. The unusual ribosomal architecture in the NMR and tuco-tuco has been speculated to be linked to high translational fidelity. Here, we show, by single-particle cryo-electron microscopy, that despite the fragmentation of their rRNA, NMR and tuco-tuco ribosomes retain their core functional architecture. Compared to ribosomes of the guinea pig, a phylogenetically related rodent without 28S rRNA fragmentation, ribosomes of NMR and tuco-tuco exhibit poorly resolved density for certain expansion segments. In contrast, the structure of the guinea pig ribosome shows high similarity to the human ribosome. Enhanced translational fidelity in the NMR and tuco-tuco may stem from subtle, allosteric effects in dynamics, linked to rRNA fragmentation.

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Primary Citation of related structures
9ZRG
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