ISDA: 9ZQV

Deposition Date 2025-12-19

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9ZQV

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of wild-type Bruton's Tyrosine Kinase (BTK) in the apo form

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.50 Å

R-Value Free:

0.20

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase BTK
Gene (Uniprot):BTK
Chain IDs:A
Chain Length:270
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q06187 Pfam ID:PF07714 EC:2.7.10.2

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
CSO	A	CYS	modified residue

Ligand Molecules

EDO

IOD

Primary Citation

Molecular and Structural Basis of Pan-Resistance to BTK Degraders and Inhibitors

Sievers, Q.Show

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Primary Citation of related structures

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