9ZNU image
Deposition Date 2025-12-14
Release Date 2026-10-21
Last Version Date 2026-10-21
Entry Detail
PDB ID:
9ZNU
Keywords:
IMMUNE SYSTEM
Title:
Cryo-EM structure of L9-yd19 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP) Kenya2-3 strain
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Plasmodium falciparum (Taxon ID: 5833)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.36 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZNU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Circumsporozoite protein
Gene (Uniprot):CSP
Chain IDs:K (auth: G)
Chain Length:335
Number of Molecules:1
Biological Source:Plasmodium falciparum
UniProt ID:Q8I9H7
Polymer Type:polypeptide(L)
Molecule:L9-yd19 heavy chain
Chain IDs:A (auth: H), C (auth: I), E (auth: J), G (auth: K), I (auth: P)
Chain Length:220
Number of Molecules:5
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:L9-yd19 light chain
Chain IDs:B (auth: L), D (auth: M), F (auth: N), H (auth: O), J (auth: Q)
Chain Length:214
Number of Molecules:5
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:L9-yd19 heavy chain
Chain IDs:L (auth: R)
Chain Length:120
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polypeptide(L)
Molecule:L9-yd19 light chain
Chain IDs:M (auth: S)
Chain Length:107
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
NA
Primary Citation
Anti-malaria antibody engineering broadens recognition motifs and reveals new homotypic interactions that enhance protective breadth.
Nat Commun 17 ? ? (2026)
PMID: 42660882 DOI: 10.1038/s41467-026-75840-w
Primary Citation of related structures
9ZNU
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