ISDA: 9ZNF

Deposition Date 2025-12-12

Release Date 2026-01-28

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9ZNF

Keywords:

RIBOSOME

Title:

Cryo-EM structure of the Methanosarcina acetivorans 70S ribosome in complex with SriA and SriB

Biological Source:

Source Organism(s):

Methanosarcina acetivorans (Taxon ID: 2214)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.03 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:23S rRNA
Chain IDs:A (auth: 1)
Chain Length:2904
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

Polymer Type:polyribonucleotide
Molecule:5S rRNA
Chain IDs:B (auth: 2)
Chain Length:133
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

Polymer Type:polyribonucleotide
Molecule:16S rRNA
Chain IDs:C (auth: 3)
Chain Length:1478
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:CBS domain-containing protein
Gene (Uniprot):HA338_08675
Chain IDs:E (auth: 4)
Chain Length:270
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832SJD6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:CBS domain-containing protein
Gene (Uniprot):HA338_08680
Chain IDs:D (auth: 5)
Chain Length:339
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832S9K2

Polymer Type:polyribonucleotide
Molecule:E-site tRNA
Chain IDs:F (auth: 8)
Chain Length:75
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2
Chain IDs:G (auth: AA)
Chain Length:238
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU4 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3
Chain IDs:H (auth: AB)
Chain Length:337
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU7 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl4
Chain IDs:I (auth: AC)
Chain Length:253
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU6 Pfam ID:PF00573

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl5
Chain IDs:J (auth: AD)
Chain Length:165
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT4 Pfam ID:PF00281, PF00673

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl6
Chain IDs:K (auth: AE)
Chain Length:176
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT1 Pfam ID:PF00347

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl7ae
Chain IDs:L (auth: AF)
Chain Length:120
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TQL9 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl13
Chain IDs:M (auth: AG)
Chain Length:143
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TT43 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl14
Chain IDs:N (auth: AH)
Chain Length:132
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT7 Pfam ID:PF00238

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl15
Chain IDs:O (auth: AI)
Chain Length:140
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRS5 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl15e
Chain IDs:P (auth: AJ)
Chain Length:196
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TPX0 Pfam ID:PF00827

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl10e
Chain IDs:Q (auth: AK)
Chain Length:173
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TU90 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl18
Chain IDs:R (auth: AL)
Chain Length:174
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRS8 Pfam ID:PF17144

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl18e
Chain IDs:S (auth: AM)
Chain Length:126
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TT44 Pfam ID:PF17135

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl19e
Chain IDs:T (auth: AN)
Chain Length:151
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832W9G6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl18a
Chain IDs:U (auth: AO)
Chain Length:61
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TIN5 Pfam ID:PF01775

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl21e
Chain IDs:V (auth: AP)
Chain Length:97
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TQU3 Pfam ID:PF01157

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl22
Chain IDs:W (auth: AQ)
Chain Length:151
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU2 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl23
Chain IDs:X (auth: AR)
Chain Length:82
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU5 Pfam ID:PF00276

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl24
Chain IDs:Y (auth: AS)
Chain Length:119
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT6 Pfam ID:PF16906, PF00467

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl24e
Chain IDs:Z (auth: AT)
Chain Length:62
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TQL7 Pfam ID:PF01246

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl29
Chain IDs:AA (auth: AU)
Chain Length:67
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU0 Pfam ID:PF00831

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl30
Chain IDs:BA (auth: AV)
Chain Length:153
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRS6 Pfam ID:PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl30e
Chain IDs:CA (auth: AW)
Chain Length:99
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRB9 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl31e
Chain IDs:DA (auth: AX)
Chain Length:89
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TIN3 Pfam ID:PF01198

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl32e
Chain IDs:EA (auth: AY)
Chain Length:129
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT0 Pfam ID:PF01655

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl37e
Chain IDs:FA (auth: AZ)
Chain Length:56
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TL48 Pfam ID:PF01907

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl39e
Chain IDs:GA (auth: Aa)
Chain Length:51
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TIN2 Pfam ID:PF00832

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl40e
Chain IDs:HA (auth: Ab)
Chain Length:49
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TJ19 Pfam ID:PF01020

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl44e
Chain IDs:IA (auth: Ac)
Chain Length:92
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832W9V9

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl37ae
Chain IDs:JA (auth: Ad)
Chain Length:94
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832SMV9

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps3ae
Chain IDs:KA (auth: BA)
Chain Length:203
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TKI9 Pfam ID:PF01015

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2
Chain IDs:LA (auth: BB)
Chain Length:225
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TT39 Pfam ID:PF00318

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps3
Chain IDs:MA (auth: BC)
Chain Length:318
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU1 Pfam ID:PF07650, PF00189

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps4
Chain IDs:NA (auth: BD)
Chain Length:218
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRR1 Pfam ID:PF01479

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps4e
Chain IDs:OA (auth: BE)
Chain Length:235
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT5 Pfam ID:PF08071, PF00900

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps5
Chain IDs:PA (auth: BF)
Chain Length:209
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRS7 Pfam ID:PF00333, PF03719

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps6e
Chain IDs:QA (auth: BG)
Chain Length:136
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TQL4 Pfam ID:PF01092

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps7
Chain IDs:RA (auth: BH)
Chain Length:189
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRC2 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps8
Chain IDs:SA (auth: BI)
Chain Length:130
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT2 Pfam ID:PF00410

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps9
Chain IDs:TA (auth: BJ)
Chain Length:134
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TT42 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps8e
Chain IDs:UA (auth: BK)
Chain Length:125
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TS82 Pfam ID:PF01201

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps10
Chain IDs:VA (auth: BL)
Chain Length:102
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:P61929 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps11
Chain IDs:WA (auth: BM)
Chain Length:126
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRR0 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps12
Chain IDs:XA (auth: BN)
Chain Length:142
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRC1 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps13
Chain IDs:YA (auth: BO)
Chain Length:162
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRR2 Pfam ID:PF00416

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps14
Chain IDs:ZA (auth: BP)
Chain Length:50
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT3 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps15
Chain IDs:AB (auth: BQ)
Chain Length:152
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TS56 Pfam ID:PF08069, PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps17-1
Chain IDs:BB (auth: BR)
Chain Length:109
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRT8 Pfam ID:PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps17e
Chain IDs:CB (auth: BS)
Chain Length:64
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8THP2 Pfam ID:PF00833

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps19
Chain IDs:DB (auth: BT)
Chain Length:136
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TRU3 Pfam ID:PF00203

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps19e
Chain IDs:EB (auth: BU)
Chain Length:149
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832W9Q0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Putative zinc finger domain-c
Gene (Uniprot):HA338_09005
Chain IDs:FB (auth: BV)
Chain Length:56
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832S8D7

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps24e
Chain IDs:GB (auth: BW)
Chain Length:101
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TJT2 Pfam ID:PF01282

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps27e
Chain IDs:HB (auth: BX)
Chain Length:62
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:P61931 Pfam ID:PF01667

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps28e
Chain IDs:IB (auth: BY)
Chain Length:76
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:Q8TQL8 Pfam ID:PF01200

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DUF5350 family protein
Gene (Uniprot):HA338_12110
Chain IDs:JB (auth: BZ)
Chain Length:57
Number of Molecules:1
Biological Source:Methanosarcina acetivorans

UniProt ID:A0A832SMB7

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details
5MC	A	C	modified residue
5MU	C	U	modified residue
6MZ	C	A	modified residue
MA6	C	A	modified residue
OMG	A	G	modified residue
OMU	A	U	modified residue

Ligand Molecules

Primary Citation

A family of archaeal hibernation factors that bind in tandem and protect ribosomes in dormant cells.

Nissley, A.J, Williams, M.C, Shulgina, Y, Kivimae, R.W, Nayak, D.D, Cate, J.H.D.Show

Biorxiv ? ? ? (2026)

PMID: 41867869 DOI: 10.64898/2026.01.19.700200

Abstact

Under nutrient limitation or stress, ribosome hibernation factors inactivate and protect ribosomes. Although ribosome hibernation plays an important role in microbes, we lack a complete understanding of this process in archaea. Here, we identify a family of hibernation factors, which we designate as single ribosomal subunit inhibitors (SriA-SriD), from the methanogenic archaeon Methanosarcina acetivorans. All four sri genes are encoded in an operon and each Sri protein inhibits protein synthesis in vitro. Deletion of sri genes in M. acetivorans impaired growth recovery after prolonged stationary phase and also led to depletion of the small ribosomal subunit. Cryo-EM structures show that Sri proteins bind to the ribosome in tandem and form conserved protein-protein interfaces. Sri is broadly distributed across archaeal phyla and sri genes frequently co-occur. Together, these findings establish Sri proteins as a distinct group of hibernation factors that protect ribosomes during dormancy and expand our understanding of ribosome hibernation in archaea.

Legend

Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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