9ZLE image
Deposition Date 2025-12-08
Release Date 2026-05-20
Last Version Date 2026-05-20
Entry Detail
PDB ID:
9ZLE
Keywords:
PROTEIN BINDING
Title:
Crystal structure of DCAF1 in complex with SDIPTAC C8
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.55 Å
R-Value Free:
0.30
R-Value Work:
0.26
R-Value Observed:
0.26
Space Group:
C 1 2 1
9ZLE validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DDB1- and CUL4-associated fac
Gene (Uniprot):DCAF1
Mutagens:F1077A, R1079A
Chain IDs:A, B, C, D, E, F
Chain Length:314
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:Q9Y4B6 EC:2.7.11.1
Ligand Molecules
A1C24
A1C25
Primary Citation
Self-dimerization Induced Proximity Targeting Chimeras (SDIPTAC) lead to DCAF1 loss of function and inhibition of HIV replication
To Be Published ? ? ? (?)
Primary Citation of related structures
9ZLE
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