ISDA: 9ZLD

Deposition Date 2025-12-08

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9ZLD

Keywords:

PROTEIN FIBRIL

Title:

Cryo-EM structure of hepatic amyloid fibril from a variant ATTRV122delta, single filament morphology

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transthyretin
Gene (Uniprot):TTR
Chain IDs:A, B, C, D, E
Chain Length:126
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:P02766 Pfam ID:PF00576

Ligand Molecules

Primary Citation

Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122 Delta amyloidosis.

Ahmed, Y, Nguyen, B.A, Kelly, C, Afrin, S, Singh, V, Evers, B.M, Shelton, J.M, Lopez Escobar, C, Singh, P, Pedretti, R, Wang, L, Bassett, P, Fernandez-Ramirez, M.D.C, Pekala, M, Lemoff, A, Kluve-Beckerman, B, Saelices, L.Show

Commun Biol ? ? ? (2026)

PMID: 41917523 DOI: 10.1038/s42003-026-09919-x

Primary Citation of related structures

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