ISDA: 9ZIR

Deposition Date 2025-12-04

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9ZIR

Keywords:

MEMBRANE PROTEIN

Title:

Crystal structure of sigma-2 receptor with zervimesine (CT1812)

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.74 Å

R-Value Free:

0.25

R-Value Work:

0.23

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Sigma intracellular receptor
Chain IDs:A, B, C, D
Chain Length:174
Number of Molecules:4
Biological Source:Bos taurus

Ligand Molecules

A1C2J

OLC

Primary Citation

Crystal Structure of the Sigma-2 Receptor Complexed with Investigational Drug Zervimesine (CT1812)

Look, G.C, Gilzer, D, Preuss, F, Wollenhaupt, J, Nitsche, J, Amaudrut, J, Malancona, S, Montalbetti, C.A, Caggiano, A.O, Hamby, M.E.Show

Acs Med.Chem.Lett. ? ? ? (2026)

DOI: 10.1021/acsmedchemlett.6c00215

Primary Citation of related structures

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