9ZGD image
Deposition Date 2025-12-02
Release Date 2026-07-08
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9ZGD
Keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
Title:
Crystal structure of VRC42.01 Fab in the presence of HIV-1 gp41 MPER peptide and phosphatidic acid (06:0 PA); unliganded form
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Human immunodeficiency virus 1 (Taxon ID: 11676)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.10 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
C 1 2 1
9ZGD validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Antibody VRC42.01 Fab heavy c
Chain IDs:A
Chain Length:228
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Antibody VRC42.01 Fab light c
Chain IDs:B
Chain Length:213
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein gp41
Chain IDs:C
Chain Length:19
Number of Molecules:1
Biological Source:Human immunodeficiency virus 1
Primary Citation
Structural basis of membrane engagement and polyreactivity control in HIV-1 MPER broadly neutralizing antibodies.
Proc.Natl.Acad.Sci.USA 123 e2609827123 e2609827123 (2026)
PMID: 42446980 DOI: 10.1073/pnas.2609827123
Primary Citation of related structures
9ZGD
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