9ZDQ image
Deposition Date 2025-11-26
Release Date 2026-09-16
Last Version Date 2026-09-16
Entry Detail
PDB ID:
9ZDQ
Keywords:
TRANSFERASE/TRANSFERASE INHIBITOR
Title:
Cryo-EM structure of ARAF-MEK1 complex with GDC-0879 and a covalent MEK inhibitor TWG-07-148
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera aff. frugiperda 1 bold-2017
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.51 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZDQ validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Chain IDs:A, C
Chain Length:273
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Dual specificity mitogen-acti
Chain IDs:B, D
Chain Length:317
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
29L
A1C1Y
ANP
Primary Citation
cryo-EM structure of ARAF-MEK1 complex with GDC-0879 and a covalent MEK inhibitor TWG-07-148
To Be Published ? ? ? (?)
Primary Citation of related structures
9ZDQ
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